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Simvastatin instructions for use.
Simvastatin
Latin name: Simvastatin
Pharmacological groups: Statins
Nosological classification (ICD-10): E78.0 Pure hypercholesterolemia. E78.2 Mixed hyperlipidemia. E78.5 Hyperlipidemia, unspecified. G45 Transient cerebral transient ischemic attacks [attacks], and related syndromes. I22 recurrent myocardial infarction. I25 Chronic ischemic heart disease. I25.1 Atherosclerotic heart disease. I25.2 of past myocardial infarction. I25.9 Chronic ischemic heart disease, unspecified. I63 Cerebral infarction. I64 Stroke, not specified as hemorrhage or infarction. I67.2 Cerebral atherosclerosis. I70 Atherosclerosis. I70.9 Generalized and unspecified atherosclerosis
Pharmacological action

The active substance (INN), Simvastatin (Simvastatin)
Application of Simvastatin: Elevated with no effect of diet, combined hypercholesterolemia and triglitseridemiya, ischemic heart disease, prevention of myocardial infarction and stroke, atherosclerosis.

Simvastatin contraindications: Hypersensitivity, acute hepatic dysfunction, severe renal insufficiency, pregnancy, lactation, childhood.

Side effects: dyspepsia, diarrhea, flatulence, nausea, exacerbation of pancreatitis and hepatitis, increase in transaminases, CNS disorders (headache, paresthesia, cramps), myalgia, asthenia, myopathy, rhabdomyolysis, photosensitization, allergic reactions (vasculitis, urticaria, arthralgia , thrombocytopenia, eosinophilia, angioedema, symptoms similar to lupus erythematosus).

Interaction: immunosuppressive therapy, high doses of nicotinic acid, antifungal agents - derivatives of the azole (ketoconazole, itraconazole) increase the risk of myopathy and rhabdomyolysis. Amplifies the effects of indirect anticoagulants, hepatotoxicity alcohol and drugs adversely affects the liver.

Dosing and dose: Inside: At the beginning of the course once at a dose of 5-10 mg / day if necessary to 40 mg per day depending on the content of cholesterol and lipoproteins in the blood. In CHD the initial dose of 20 mg / day once.

Precautions: Before and during treatment is recommended to monitor liver function and caution is prescribed for its violation.


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